Pediatric hematologist/oncologist Dr. Sherron Jackson lays out some of the early presenting symptoms associated with sickle cell disease, focusing on pain. She describes how the location of pain moves from extremities in infants to become more centralized as a child with sickle cell disease ages. She also notes the increase in both frequency and intensity of sickling episodes with age. Dr. Jackson talks about how she, as a physician, aids patients in pain management. She concludes this podcast by mentioning how life expectancy is affected by sickle cell disease.