171 Ashley Ave.
Charleston, SC 29425
843-792-1414
800-424-MUSC
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Charles P. Darby Children's Research Institute
The CRI investigators at MUSC are dedicating their lives to understanding children's diseases
and to helping our children lead lives that are as closest to normal as possible by developing
innovative, effective and safe treatments. Below is a description of the research projects currently
being conducted in the Children's Research Institute.
Second Floor
Pediatric Obesity, Insulin Resistance, and Diabetes
Program director: L. Lyndon Key, MD
Research focus: Obesity, insulin resistance, and diabetes.
Childhood Autoimmune Rheumatic Diseases
Program directors: Richard Silver, MD, Stephen Tomlinson, PhD, and Gary Gilkeson, MD
Research focus: Juvenile idiopathic arthritis, lupus and other disease manifestations having
immunemedicated mechanisms of pathogenesis similar to lupus.
Osteoclast Biology and Bone Disease
Program director: Sakamuri Reddy, PhD
Research focus: Healthy bone development, prevention of bone disease and new treatments for bone disease.
Osteoclast team.
Renal Biology
Program director: P. Darwin Bell, PhD
Research focus:
Third Floor
Antenatal and Early Childhood Nutrition
Program directors: Bruce W. Hollis, PhD and Carol Wagner, MD
Research focus: Antenatal and neonatal nutrition and disease.
Pediatric Pulmonary Biology
Program director: John E. Baatz, PhD
Research focus: Developmental pulmonary biology, cystic fibrosis, lung injury and inflammation, lung toxicity
and disease indigenous to South Carolina and to Southeastern coastal regions.
Proteomics Center
Program director: Daniel Knapp, PhD
Program goals: To promote and facilitate application of proteomic analysis to research at MUSC, to provide
research training in proteomics methodologies, and to advance the technologies for proteomic analysis
Clemson University - MUSC Bioengineering Program
Program director: Richard Swaja, PhD
Research focus: The development of new equipment needed to perform cutting-edge biomedical research.
Fourth Floor
Pediatric Neuropsychiatry
Program director: Peter Kalivas, PhD
Research goals: To explore how aberrations in brain development can cause disorders such as addiction,
depression, attention deficit disorder, obsessive compulsive disorder and conduct disorder.
Developmental Neuroscience
Program director: Prakash Kara, PhD
Research focus: Special aspects of brain development, repair and regeneration.
Genetic Basis of Developmental Disabilities
Program director: G. Shashidhar Pai, MD
Research goals: To identify genetic predispositions and the pathophysiology of small, well-defined group
of related disorders, including autism spectrum disorders and related genetic syndromes.
Childhood Cancer and Blood Disorders
Program director: Bernard Maria, MD and Jacqueline Kraveka, MD
Research goals: To provide insights into the molecular pathogenesis of the aberrant cellular development and
stem differentiation in common pediatric cancers such as leukemia, brain tumors and neuroblastoma, and in pediatric
sickle cell anemia.
Drug Disposition and Pharmacogenetics
Program director: C. Lindsay DeVane, PharmD
Research goals: To better understand the roles of drug disposition and pharmacogenetics in the response to drugs
in order to improve outcomes of drug treatment. By co-locating this program with molecular genetics, developmental
neuroscience, pediatric neuropsychiatry, and cancer programs, there are opportunities for synergies in research
that would examine drug effects in brain disorders and in cancer.
Fifth Floor
Developmental Neurological Disorders
Program director: Inderjit Singh, PhD
Research focus: Normal brain development, neurodegenerative disorders and translational research for
neuroprotective and neuroregenerative therapeutics. the program will focus on the major causes of developmental
disabilities, including the disease mechanisms of birth defect disorders, perinatal insults, cerebral palsy
and inherited disorders. As part of this program, researchers will examine the functional roles of
sphingolipids in the development of childhood diseases such as neurodegenerative disorders, childhood
cancers, vascular diseases and diabetes.
Sixth Floor
Pediatric Cardiogenomic Biology & Cardiovascular Developmental Biology
Program directors: Roger Markwald, PhD, and J. Phillip Saul, MD
Program goals: Identifying the genetic causes of congenital heart disease and the impact of the genome on cardiac phenotype; better
understanding abnormal coronary vascular development; exploring potential approaches for in vivo repair of heart defects in children;
and engineering tissue replacements for structurally defective newborn hearts or diseased adult cardiac structures.
In addition, bioengineers from the Clemson University/MUSC bioengineering program will work alongside cardiovascular researchers to develop
novel devices and approaches to treat congenital heart disease.
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